Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro.

@article{Ahmed2005PunicaGL,
  title={Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro.},
  author={Salahuddin Ahmed and Naizhen Wang and Bilal Bin Hafeez and Vinay K. Cheruvu and Tariq M Haqqi},
  journal={The Journal of nutrition},
  year={2005},
  volume={135 9},
  pages={2096-102}
}
Interleukin (IL)-1beta induces the expression of matrix metalloproteinases (MMPs) implicated in cartilage resorption and joint degradation in osteoarthritis (OA). Pomegranate fruit extract (PFE) was recently shown to exert anti-inflammatory effects in different disease models. However, no studies have been undertaken to investigate whether PFE constituents protect articular cartilage. In the present studies, OA chondrocytes or cartilage explants were pretreated with PFE and then stimulated with… CONTINUE READING

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