Pumilio facilitates miRNA regulation of the E2F3 oncogene.

  title={Pumilio facilitates miRNA regulation of the E2F3 oncogene.},
  author={Wayne O. Miles and Katrin Tsch{\"o}p and Anabel Herr and Jun-Yuan Ji and Nicholas J. Dyson},
  journal={Genes & development},
  volume={26 4},
E2F transcription factors are important regulators of cell proliferation and are frequently dysregulated in human malignancies. To identify novel regulators of E2F function, we used Drosophila as a model system to screen for mutations that modify phenotypes caused by reduced levels of dE2F1. This screen identified components of the Pumilio translational repressor complex (Pumilio, Nanos, and Brain tumor) as suppressors of dE2F1-RNAi phenotypes. Subsequent experiments provided evidence that… CONTINUE READING
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