Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Abstract

The ability of the retinoblastoma protein (RB) tumor suppressor to repress transcription stimulated by the E2 promoter binding factors (E2F) is integral to its biological functions. Our recent report described a conserved feedback mechanism mediated by the RNA-binding proteins Pumilio and Nanos that increases in importance following RB loss and helps cells… (More)
DOI: 10.4161/23723548.2014.968074

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Cite this paper

@article{Miles2014PumilioAN, title={Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.}, author={Wayne O. Miles and Nicholas J. Dyson}, journal={Molecular & cellular oncology}, year={2014}, volume={1 4}, pages={e968074} }