Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

@article{Steckley2007PumaIA,
  title={Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.},
  author={Diana C. Steckley and Meera Karajgikar and Lianne B. Dale and Ben Fuerth and Patrick Swan and Chris Drummond-Main and Michael O Poulter and Stephen S. G. Ferguson and Andreas Strasser and Sean P. Cregan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 47},
  pages={12989-99}
}
Oxidative stress has been implicated as a key trigger of neuronal apoptosis in stroke and neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The Bcl-2 homology 3 (BH3)-only subfamily of Bcl-2 genes consists of multiple members that can be activated in a cell-type- and stimulus-specific manner to promote cell death. In the present study, we demonstrate that, in cortical neurons, oxidative stress induces the expression of the BH3-only… CONTINUE READING

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