Puma, a critical mediator of cell death — one decade on from its discovery

@article{Hikisz2012PumaAC,
  title={Puma, a critical mediator of cell death — one decade on from its discovery},
  author={Paweł Hikisz and Zofia M. Kiliańska},
  journal={Cellular & Molecular Biology Letters},
  year={2012},
  volume={17},
  pages={646-669}
}
PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent apoptosis and was identified 10 years ago. The PUMA gene is mapped to the long arm of chromosome 19, a region that is frequently deleted in a large number of human cancers. PUMA mediates apoptosis thanks to its ability to directly bind known anti-apoptotic members of the Bcl-2 family. It mainly localizes to the… CONTINUE READING
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