Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock.

@article{SozaRied2014PulsesON,
  title={Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock.},
  author={Cristian Soza-Ried and Emre {\"O}zt{\"u}rk and D. Ish-Horowicz and Julian Lewis},
  journal={Development},
  year={2014},
  volume={141 8},
  pages={1780-8}
}
Formation of somites, the rudiments of vertebrate body segments, is an oscillatory process governed by a gene-expression oscillator, the segmentation clock. This operates in each cell of the presomitic mesoderm (PSM), but the individual cells drift out of synchrony when Delta/Notch signalling fails, causing gross anatomical defects. We and others have suggested that this is because synchrony is maintained by pulses of Notch activation, delivered cyclically by each cell to its neighbours, that… CONTINUE READING
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