Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids.

  title={Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids.},
  author={Stephanie Grainger and Juliana Valencia Serna and Steffi Sunny and Yun Zhou and Cheri X. Deng and Mohamed E. H. El-sayed},
  journal={Molecular pharmaceutics},
  volume={7 6},
Effective treatment of solid tumors requires homogeneous distribution of anticancer drugs within the entire tumor volume to deliver lethal concentrations to resistant cancer cells and tumor-initiating cancer stem cells. However, penetration of small molecular weight chemotherapeutic agents and drug-loaded polymeric and lipid particles into the hypoxic and necrotic regions of solid tumors remains a significant challenge. This article reports the results of pulsed ultrasound enhanced penetration… CONTINUE READING


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