Pulsed stable isotope-resolved metabolomic studies of cancer cells.

@article{Pietzke2014PulsedSI,
  title={Pulsed stable isotope-resolved metabolomic studies of cancer cells.},
  author={Matthias Pietzke and Stefan Kempa},
  journal={Methods in enzymology},
  year={2014},
  volume={543},
  pages={
          179-98
        }
}
Metabolic reprogramming is a key step in oncogenic transformation, and it involves alterations in both bioenergetic and anabolic metabolism. Sustained by these metabolic alterations, malignant cells acquire the ability to re-enter the cell cycle and proliferate. The so-called central carbon metabolism (CCM) is the ultimate source for energy and building blocks enabling cellular growth and proliferation. The time-resolved monitoring of the conversion of stable isotope-labeled metabolites… CONTINUE READING
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