Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region

@article{Richards2008PulsedRD,
  title={Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region},
  author={Gregory M. Richards and Wolfgang A. Tom{\'e} and Hillary Robins and James A Stewart and James Welsh and Peter Mahler and Steven P. Howard},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={114},
  pages={307-313}
}
Purpose Reirradiation of breast cancer locoregional recurrence (LRR) in the setting of prior post-mastectomy radiation poses a significant clinical challenge due to the high risk for severe toxicity. In an attempt to reduce these toxicities, we have developed pulsed reduced dose-rate radiotherapy (PRDR), a reirradiation technique in which a series of 0.2 Gy pulses separated by 3-min time intervals is delivered, creating an apparent dose rate of 0.0667 Gy/min. Here we describe our early… CONTINUE READING
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