Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice.

@article{Khaibullina2008PulsedHF,
  title={Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice.},
  author={Alfia Khaibullina and Beom-su Jang and Haihao Sun and Nhat X. T. Le and Sarah Yu and Victor Frenkel and Jorge A. Carrasquillo and Ira Pastan and King Chuen Li and Chang H Paik},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2008},
  volume={49 2},
  pages={295-302}
}
UNLABELLED The aim of this study was to determine if pulsed high-intensity focused ultrasound (HIFU) exposures could enhance tumor uptake of (111)In-MX-B3, a murine IgG1kappa monoclonal antibody directed against the Le(y) antigen. METHODS MX-B3 was labeled with (111)In, purified, and confirmed for its binding to the antigen-positive A431 cell line. Groups of nude mice were inoculated subcutaneously with A431 tumor cells on both hind flanks. A tumor on one flank was treated with pulsed-HIFU… CONTINUE READING
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