Pulsed electromagnetic fields promote in vitro osteoblastogenesis through a Wnt/β-catenin signaling-associated mechanism.

@article{Zhai2016PulsedEF,
  title={Pulsed electromagnetic fields promote in vitro osteoblastogenesis through a Wnt/β-catenin signaling-associated mechanism.},
  author={Mingming Zhai and Da Jing and Shichao Tong and Yan Ting Wu and Pan Wang and Zhaobin Zeng and Guanghao Shen and Xin Wang and Qiaoling Xu and Erping Luo},
  journal={Bioelectromagnetics},
  year={2016},
  volume={37 3},
  pages={
          152-162
        }
}
Substantial evidence indicates that pulsed electromagnetic fields (PEMF) could accelerate fracture healing and enhance bone mass, whereas the unclear mechanism by which PEMF stimulation promotes osteogenesis limits its extensive clinical application. In the present study, effects and potential molecular signaling mechanisms of PEMF on in vitro osteoblasts were systematically investigated. Osteoblast-like MC3T3-E1 cells were exposed to PEMF burst (0.5, 1, 2, or 6 h/day) with 15.38 Hz at various… CONTINUE READING
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