Pulsed controlled-released system for potential use in vaccine delivery.

@article{Snchez1996PulsedCS,
  title={Pulsed controlled-released system for potential use in vaccine delivery.},
  author={Alejandro S{\'a}nchez and Rajesh K. Gupta and Maribel Jim{\'e}nez Alonso and George R. Siber and Robert Langer},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 6},
  pages={
          547-52
        }
}
Biodegradable polymeric devices intended to provide a viable route for single-dose vaccination were developed using controlled-release technology. One of the main challenges in the development of these devices was to overcome several water-mediated inactivation processes that occur in conventional polymeric systems. Our strategy was focused on the prevention of antigen exposure to environmental conditions. For this purpose a microencapsulation process was designed and optimized to provide an… CONTINUE READING
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