Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials.

@article{Murphy2011PulsedAS,
  title={Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials.},
  author={Kevin Murphy and Ashley D. Harris and Ana Diukova and C. John Evans and David J. Lythgoe and Fernando Zelaya and Richard G. Wise},
  journal={Magnetic resonance imaging},
  year={2011},
  volume={29 10},
  pages={1382-9}
}
Pulsed arterial spin labeling (PASL) is an increasingly common technique for noninvasively measuring cerebral blood flow (CBF) and has previously been shown to have good repeatability. It is likely to find a place in clinical trials and in particular the investigation of pharmaceutical agents active in the central nervous system. We aimed to estimate the sample sizes necessary to detect regional changes in CBF in common types of clinical trial design including (a) between groups, (b) a two… CONTINUE READING

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