Pulse exposure of cultured rat neurons to aluminum-maltol affected the axonal transport system.

@article{Kashiwagi1998PulseEO,
  title={Pulse exposure of cultured rat neurons to aluminum-maltol affected the axonal transport system.},
  author={Yukiyasu Kashiwagi and Yu A. Nakamura and Y Miyamae and Ryota Hashimoto and Masatoshi Takeda},
  journal={Neuroscience letters},
  year={1998},
  volume={252 1},
  pages={5-8}
}
Although chronic aluminum neurotoxicity has been well established, the mechanism of the toxicity has not been elucidated yet. In order to simplify the study of the aluminum neurotoxicity, we employed the pulse exposure of cultured rat cortical neurons to 250 microM aluminum-maltol for 1 h at the early stage (6 h after plating), which resulted in abnormal distribution of neurofilament L (NFL) and fast axonal transported proteins, whereas the axonal transport of tubulin, actin, and clathrin were… CONTINUE READING