Pulse duration and peak intensity during focused ultrasound surgery: theoretical and experimental effects in rabbit brain in vivo.

@article{Vykhodtseva1994PulseDA,
  title={Pulse duration and peak intensity during focused ultrasound surgery: theoretical and experimental effects in rabbit brain in vivo.},
  author={Natalia Vykhodtseva and Kullervo Hynynen and Christakis Damianou},
  journal={Ultrasound in medicine & biology},
  year={1994},
  volume={20 9},
  pages={987-1000}
}
The goal of this study was to establish the exposure parameters that will generate predictable thermally induced lesions in brain. In addition, the accuracy of a theoretical model for prediction of the lesion size was tested. To do this, 160 adult rabbits were sonicated (frequency 0.936 and 1.72 MHz) and then sacrificed at various intervals after the sonications. The results showed that predictable thermal lesions could be induced if the exposure durations were between 0.5 and 2 s. Dimensions… CONTINUE READING

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