Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes--a cytoskeleton-dependent process.

@article{Ajubi1996PulsatingFF,
  title={Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes--a cytoskeleton-dependent process.},
  author={Nasser E Ajubi and Jenneke Klein-Nulend and Peter J. Nijweide and T. Vrijheid-Lammers and Marcel J Alblas and Elisabeth H. Burger},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={225 1},
  pages={62-8}
}
It has been postulated that the transduction of mechanical stress signals to bone cells occurs via loading-dependent flow of interstitial fluid through the lacuno-canalicular network of bone. We have shown earlier that chicken osteocytes release enhanced amounts of prostaglandin E2 after 1 h treatment with pulsating fluid flow (PFF, 0.5 +/- 0.02 Pa, 5 Hz). Here we study the acute response to PFF on three cell populations derived from fetal chick calvariae, namely periosteal fibroblasts (PF), an… CONTINUE READING

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