Pulsatility of insulin release – a clinically important phenomenon

  title={Pulsatility of insulin release – a clinically important phenomenon},
  author={B H Hellman},
  booktitle={Upsala journal of medical sciences},
The mechanisms and clinical importance of pulsatile insulin release are presented against the background of more than half a century of companionship with the islets of Langerhans. The insulin-secreting beta-cells are oscillators with intrinsic variations of cytoplasmic ATP and Ca(2+). Within the islets the beta-cells are mutually entrained into a common rhythm by gap junctions and diffusible factors (ATP). Synchronization of the different islets in the pancreas is supposed to be due to… CONTINUE READING


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