Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.

@article{Seko1999PulsatileSA,
  title={Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.},
  author={Yoshinori Seko and Naoyuki Takahashi and Kazuyuki Tobe and Takashi Kadowaki and Yoshio Yazaki},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={259 1},
  pages={8-14}
}
Recently, we demonstrated that pulsatile mechanical stretch induced rapid secretion of vascular endothelial growth factor (VEGF) by cultured rat cardiac myocytes in vitro. To investigate whether pulsatile stretch activates intracellular signaling in cardiac myocytes, we examined the activation of mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. We found that pulsatile stretch rapidly phosphorylated p44/p42 MAPKs… CONTINUE READING
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