Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis.

@article{Buschmann2010PulsatileSA,
  title={Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis.},
  author={Ivo R. Buschmann and Axel Radlach Pries and Beata Styp-Rekowska and Philipp Hillmeister and Laurent Loufrani and Daniel Henrion and Yu Shi and Andr{\'e} Duelsner and Imo Hoefer and Nora Gatzke and Haitao Wang and Kerstin Lehmann and Lena Ulm and Zully Ritter and Peter Hauff and Ruslan Hlushchuk and Valentin Djonov and Toon A. B. van Veen and Ferdinand le Noble},
  journal={Development},
  year={2010},
  volume={137 13},
  pages={2187-96}
}
In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline vasculature in vivo. The best discrimination between arteries and veins was obtained by calculating the maximal… CONTINUE READING
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