Pulsatile myocardial tubes fabricated with cell sheet engineering.

  title={Pulsatile myocardial tubes fabricated with cell sheet engineering.},
  author={Hidekazu Sekine and Tatsuya Shimizu and Joseph Yang and Eiji Kobayashi and T. Okano},
  volume={114 1 Suppl},
BACKGROUND Tissue engineering approaches involving the direct transplantation of cardiac patches have received significant attention as alternative methods for the treatment of damaged hearts. In contrast, we used cardiomyocyte sheets harvested from temperature-responsive culture dishes to create pulsatile myocardial tubes and examined their in vivo function and survival. METHODS AND RESULTS Neonatal rat cardiomyocyte sheets were sequentially wrapped around a resected adult rat thoracic aorta… CONTINUE READING