Pulsatile luteinizing hormone secretion in normal female mice and in hypogonadal female mice with preoptic area implants.

@article{Gibson1991PulsatileLH,
  title={Pulsatile luteinizing hormone secretion in normal female mice and in hypogonadal female mice with preoptic area implants.},
  author={Marie J Gibson and Gregory M. Miller and A J Silverman},
  journal={Endocrinology},
  year={1991},
  volume={128 2},
  pages={965-71}
}
Pulsatile LH secretion is driven by GnRH, the hypothalamic hormone that is lacking in the hypogonadal mutant mouse. Preoptic area grafts containing GnRH neurons correct many reproductive deficits in hypogonadal mice. In this study we evaluated the pattern of LH secretion in hypogonadal female mice with preoptic area grafts (hpg/POA) and in normal female mice. Normal females were ovariectomized at 10 weeks of age, and hpg/POA mice were ovariectomized 4 months after graft surgery. Three weeks… CONTINUE READING

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