Pulsatile local delivery of thrombolytic and antithrombotic agents using poly( N-isopropylacrylamide-co-methacrylic acid) hydrogels

Abstract

Hydrogels of poly(N-isopropylacrylamide-co-methacrylic acid) were synthesized and investigated as pHand temperature-triggered delivery devices for antithrombotic agents. For hydrogels containing greater than 75 tool% N1PAAm, the pH and temperature sensitivity both influenced the overall swelling behavior of the networks. Streptokinase and heparin were… (More)

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