Pulsatile insulin secretion: detection, regulation, and role in diabetes.

  title={Pulsatile insulin secretion: detection, regulation, and role in diabetes.},
  author={Niels K P\orksen and Malene Hollingdal and C. B. Juhl and Peter C Butler and Johannes D. Veldhuis and Ole Schmitz},
  volume={51 Suppl 1},
Insulin concentrations oscillate at a periodicity of 5-15 min per oscillation. These oscillations are due to coordinate insulin secretory bursts, from millions of islets. The generation of common secretory bursts requires strong within-islet and within-pancreas coordination to synchronize the secretory activity from the beta-cell population. The overall contribution of this pulsatile mechanism dominates and accounts for the majority of insulin release. This review discusses the methods involved… CONTINUE READING

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Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass

  • N Porksen, SR Munn, JL Steers, JD Veldhuis, PC Butler
  • Am J Physiol 270:E1043–E1049,
  • 1996
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