Pulsatile human corticotropin-releasing hormone prevents dexamethasone-induced suppression of the plasma cortisol response to hypoglycemia in normal men.

@article{Avgerinos1992PulsatileHC,
  title={Pulsatile human corticotropin-releasing hormone prevents dexamethasone-induced suppression of the plasma cortisol response to hypoglycemia in normal men.},
  author={Peter Avgerinos and Christos Kiamouris and I P Petrakos and I K Kleanthous and P A Zorzos and T N Dimitriadis and Sotirios Raptis and Gordon B. Cutler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 5},
  pages={1358-61}
}
Insulin-induced hypoglycemia causes a sequential stimulation of all three components of the hypothalamic-pituitary-adrenal axis. States of acute glucocorticoid excess, such as the overnight (1 mg) dexamethasone suppression test (DST), inhibit both the basal cortisol level and the response to an insulin tolerance test (ITT). However, whether this negative… CONTINUE READING