Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver.

  title={Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver.},
  author={Jan Oscarsson and Cissi Gardmo and Staffan Ed{\'e}n and Agneta Mode},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={280 2},
S-adenosylmethionine synthetase (AdoMet synthetase) is responsible for the synthesis of the major methyl donor S-adenosylmethionine. The AdoMet synthetase gene was identified by subtractive suppressive hybridization as being expressed at higher levels in the liver of rats continuously exposed to growth hormone (GH) than in rats intermittently exposed to the hormone. Further studies on the regulation of AdoMet synthetase showed that the activity and mRNA levels were higher in female than in male… CONTINUE READING

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