Pulsatile GnRH regulation of gonadotropin subunit gene transcription.


We investigated the requirement for gonadotropin-releasing hormone (GnRH) release in vivo and the pattern of GnRH administration in vitro on the expression of the gonadotropin subunit genes in female rats. Injection of the GnRH antagonist ([Nal-Lys] GnRH; 30 micrograms/100g bw) to ovariectomized rats rapidly suppressed transcription of the alpha-subunit and… (More)