Pulsatile Cortisol Feedback on ACTH Secretion Is Mediated by the Glucocorticoid Receptor and Modulated by Gender.

@article{Roelfsema2016PulsatileCF,
  title={Pulsatile Cortisol Feedback on ACTH Secretion Is Mediated by the Glucocorticoid Receptor and Modulated by Gender.},
  author={F. Roelfsema and Paul Aoun and J. Veldhuis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2016},
  volume={101 11},
  pages={
          4094-4102
        }
}
  • F. Roelfsema, Paul Aoun, J. Veldhuis
  • Published 2016
  • Medicine
  • The Journal of clinical endocrinology and metabolism
  • CONTEXT Factors that regulate physiological feedback by pulses of glucocorticoids on the hypothalamic-pituitary unit are sparsely defined in humans in relation to gluco- or mineralocorticoid receptor pathways, gender, age, and the sex steroid milieu. OBJECTIVE The objective of the study was to test (the clinical hypothesis) that glucocorticoid (GR) and mineralocorticoid (MR) receptor-selective mechanisms differentially govern pulsatile cortisol-dependent negative feedback on ACTH output (by… CONTINUE READING
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