Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation.

@article{Doi2000PulmonaryVB,
  title={Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation.},
  author={Shouzaburoh Doi and Nicholas Smedira and Paul A. Murray},
  journal={Journal of applied physiology},
  year={2000},
  volume={88 1},
  pages={210-8}
}
We tested the hypothesis that regulation of the pulmonary circulation by endogenous endothelin (ET) during normoxia and hypoxia was altered in conscious dogs 1 mo after left lung autotransplantation (LLA). Sham-operated control and post-LLA dogs were chronically instrumented to measure the left pulmonary vascular pressure-flow (LP-Q) relationship. LP-Q plots were generated on separate days during normoxia and hypoxia (arterial PO(2) approximately 50 Torr) in the intact condition, after… CONTINUE READING
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