Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension.

@article{Adrie1998PulmonaryVB,
  title={Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension.},
  author={Christophe Adrie and Fumito Ichinose and Alois Holzmann and Lee Keefer and William E. Hurford and Warren M. Zapol},
  journal={Journal of applied physiology},
  year={1998},
  volume={84 2},
  pages={435-41}
}
Sodium 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO; Et2N-[N(O)NO]Na) is a compound that spontaneously generates nitric oxide (NO). Because of its short half-life (2.1 min), we hypothesized that inhaling DEA/NO aerosol would selectively dilate the pulmonary circulation without decreasing systemic arterial pressure. We compared the pulmonary selectivity of this new NO donor with two other reference drugs: inhaled NO and inhaled sodium nitroprusside (SNP). In seven awake sheep with… CONTINUE READING