Pulmonary vasodilation by ketamine is mediated in part by L-type calcium channels.

@article{Kaye1998PulmonaryVB,
  title={Pulmonary vasodilation by ketamine is mediated in part by L-type calcium channels.},
  author={Alan D. Kaye and Ronald E. Banister and Muhuddin Rajin Anwar and Chang Jian Feng and Philip J. Kadowitz and Bobby Dean Nossaman},
  journal={Anesthesia and analgesia},
  year={1998},
  volume={87 4},
  pages={956-62}
}
UNLABELLED We studied the effects of ketamine in the isolated rat lung under conditions of increased pulmonary arterial pressure using the thromboxane A2 mimic, U46619, and in response to ventilatory hypoxia. Ketamine caused dose-dependent vasodilation, and possible mechanisms were evaluated using verapamil, meclofenamate, N(omega)-L-nitro-L-arginine benzyl ester (an inhibitor of nitric oxide synthase), and U-38883A (an ATP-sensitive potassium channel antagonist) in the isolated blood-perfused… CONTINUE READING

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