Pulmonary vasoconstrictor action of KCNQ potassium channel blockers

  title={Pulmonary vasoconstrictor action of KCNQ potassium channel blockers},
  author={Shreena Joshi and Prabhu Balan and Alison M Gurney},
  journal={Respiratory Research},
  pages={31 - 31}
BACKGROUND KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K+ currents mediated by KCNQ channels resemble a current underlying the resting K+ conductance and resting potential of pulmonary artery smooth muscle cells. We therefore… CONTINUE READING


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DuP 996(3,3-bis(4pyridinylmethyl)-1-phenylindolin-2-one) enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo

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