Pulmonary vascular resistance in adult rats exposed to hypoxia in the neonatal period.

@article{Hakim1990PulmonaryVR,
  title={Pulmonary vascular resistance in adult rats exposed to hypoxia in the neonatal period.},
  author={Tawfic S. Hakim and J P Mortola},
  journal={Canadian journal of physiology and pharmacology},
  year={1990},
  volume={68 3},
  pages={419-24}
}
Newborn rats were exposed to hypoxia (10% O2 + N2) from 24 h to day 6 of neonatal life and then returned to room air until 45 days of age (experimental). The rats were anaesthetized, heparinized, and exsanguinated. The chest was opened and the lungs were perfused with diluted autologous blood at a constant flow rate (Q). The pulmonary arterial pressure (Pa) and venous pressure (Pv) were monitored. The properties of the pulmonary vasculature were assessed by measuring baseline vascular… CONTINUE READING