Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice.

  title={Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice.},
  author={Patrice M. Becker and Armina A. Kazi and Raj Wadgaonkar and David B. Pearse and David Kwiatkowski and Joe G. N. Garcia},
  journal={American journal of respiratory cell and molecular biology},
  volume={28 4},
Gelsolin is a potent actin filament regulatory protein that controls cytoskeletal assembly and disassembly. Because cellular gelsolin deficiency leads to pronounced actin stress fiber formation and defective chemotaxis, and similar cytoskeletal remodeling results in endothelial barrier dysfunction, we hypothesized that gelsolin deficient mice would exhibit increased vascular permeability. To test this hypothesis, we compared baseline lung lavage (BAL) protein concentration, wet/dry weight ratio… CONTINUE READING


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