Pulmonary vascular effects of fat emulsion infusion in unanesthetized sheep. Prevention by indomethacin.

@article{McKeen1978PulmonaryVE,
  title={Pulmonary vascular effects of fat emulsion infusion in unanesthetized sheep. Prevention by indomethacin.},
  author={C R McKeen and Kenneth L. Brigham and R E Bowers and T. R. Harris},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={61 5},
  pages={1291-7}
}
Pulmonary diffusing capacity and arterial blood Po(2) decrease in humans when 10% fat emulsion is infused. To study its effects on the pulmonary circulation and lung fluid balance, we infused 0.25 g/kg x h of a 10% fat emulsion (Intralipid, Cutter Laboratories, Inc., Berkeley, Calif.) into an awake sheep lung lymph preparation. The emulsion caused a sustained increase in pulmonary artery pressure to approximately twice base line with little change in left atrial pressure. Pa(O2) decreased an… CONTINUE READING
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