Pulmonary vascular balance in congenital diaphragmatic hernia: enhanced endothelin-1 gene expression as a possible cause of pulmonary vasoconstriction.

@article{Okazaki1998PulmonaryVB,
  title={Pulmonary vascular balance in congenital diaphragmatic hernia: enhanced endothelin-1 gene expression as a possible cause of pulmonary vasoconstriction.},
  author={Tadaharu Okazaki and Hari Shanker Sharma and S. K. Mccune and D Tibboel},
  journal={Journal of pediatric surgery},
  year={1998},
  volume={33 1},
  pages={
          81-4
        }
}
BACKGROUND Pulmonary hypoplasia and persistent pulmonary hypertension (PPH) are the principal causes of the ongoing mortality in congenital diaphragmatic hernia (CDH) presenting with respiratory insufficiency within 6 hours after birth. Endothelin-1 (ET-1) is an endothelial-derived vasoconstrictor, which could play an important role in modulating pulmonary vascular tone in PPH. ET-1 exerts its role in controlling vascular tone through two different subtype receptors, endothelin-A receptor (ETA… CONTINUE READING
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