Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation

  title={Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation},
  author={Yasuo Morimoto and Hiroto Izumi and Yukiko Yoshiura and Taisuke Tomonaga and Takako Oyabu and Toshihiko Myojo and Kazuaki Kawai and Kazuhiro Yatera and Manabu Shimada and Masaru Kubo and Kazuhiro Yamamoto and Shinichi Kitajima and Etsushi Kuroda and Kenji Kawaguchi and Takeshi Sasaki},
  booktitle={Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology},
We performed inhalation and intratracheal instillation studies of cerium dioxide (CeO2) nanoparticles in order to investigate their pulmonary toxicity, and observed pulmonary inflammation not only in the acute and but also in the chronic phases. In the intratracheal instillation study, F344 rats were exposed to 0.2 mg or 1 mg of CeO2 nanoparticles. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the instillation. In the… CONTINUE READING
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Aerosol generation by a spray-drying technique under coulomb explosion and rapid evaporation for the preparation of aerosol particles for inhalation tests

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Dose-dependent pulmonary response of well-dispersed titanium dioxide nanoparticles following intratracheal instillation

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