Pulmonary toxicity in mice by 2- and 13-week inhalation exposures to indium-tin oxide and indium oxide aerosols.

@article{Nagano2011PulmonaryTI,
  title={Pulmonary toxicity in mice by 2- and 13-week inhalation exposures to indium-tin oxide and indium oxide aerosols.},
  author={Kasuke Nagano and Tomoshi Nishizawa and Yoko Eitaki and Makoto Ohnishi and Tadashi Noguchi and Heihachiro Arito and Shoji Fukushima},
  journal={Journal of occupational health},
  year={2011},
  volume={53 3},
  pages={
          234-9
        }
}
OBJECTIVES Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk at 0, 0.1or 1 mg/m(3). RESULTS ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis… CONTINUE READING

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