Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU).

  title={Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU).},
  author={John R. Durant and Michael J. Norgard and Tarek Murad and Alfred A. Bartolucci and Katherine H. Langford},
  journal={Annals of internal medicine},
  volume={90 2},
Ten patients developed pulmonary fibrosis after bischloroethylnitrosourea (BCNU) therapy for malignancy. This was lethal in seven patients, four of whom had no evidence of tumor at autopsy. Presenting symptoms were either the insidious onset of cough and dyspnea or the sudden onset of respiratory failure. Physical findings were unremarkable. Chest roentgenogram usually showed interstitial infiltrates. Pulmonary function studies showed resting hypoxia with diffusion and restrictive defects. This… CONTINUE READING