Pulmonary surfactant function is abolished by an elevated proportion of cholesterol.

@article{Gunasekara2005PulmonarySF,
  title={Pulmonary surfactant function is abolished by an elevated proportion of cholesterol.},
  author={Lasantha Chandrajeewa Gunasekara and Samuel Schuerch and W. Michael Schoel and K. Nandaki Nag and Zoya Leonenko and Michael G. Haufs and Matthias Walter Amrein},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1737 1},
  pages={
          27-35
        }
}
A molecular film of pulmonary surfactant strongly reduces the surface tension of the lung epithelium-air interface. Human pulmonary surfactant contains 5-10% cholesterol by mass, among other lipids and surfactant specific proteins. An elevated proportion of cholesterol is found in surfactant, recovered from acutely injured lungs (ALI). The functional role of cholesterol in pulmonary surfactant has remained controversial. Cholesterol is excluded from most pulmonary surfactant replacement… CONTINUE READING
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