Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.

@article{Dobbs1987PulmonarySA,
  title={Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.},
  author={Leland G. Dobbs and Jo Rae Wright and Samuel B Hawgood and Roc{\'i}o Gonz{\'a}lez and Kristine Venstrom and J Nellenbogen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 4},
  pages={
          1010-4
        }
}
Pulmonary surfactant is synthesized and secreted by alveolar type II cells. Radioactive phosphatidylcholine has been used as a marker for surfactant secretion. We report findings that suggest that surfactant inhibits secretion of 3H-labeled phosphatidylcholine by cultured rat type II cells. The lipid components and the surfactant protein group of Mr 26,000-36,000 (SP 26-36) inhibit secretion to different extents. Surfactant lipids do not completely inhibit release; in concentrations of 100… CONTINUE READING

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