Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect.

@article{Fischer2009PulmonaryPI,
  title={Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect.},
  author={Uwe M. Fischer and Matthew T Harting and Fernando Jim{\'e}nez and Werner O Monzon-Posadas and Hasen Xue and Sean Isaac Savitz and Glen A. Laine and Charles S. Cox},
  journal={Stem cells and development},
  year={2009},
  volume={18 5},
  pages={683-92}
}
Intravenous (IV) stem cell delivery for regenerative tissue therapy has been increasingly used in both experimental and clinical trials. However, recent data suggest that the majority of administered stem cells are initially trapped in the lungs. We sought to investigate variables that may affect this pulmonary first-pass effect. In anesthetized Sprague-Dawley rats, silicone tubing catheters were placed in the left internal jugular vein and common carotid artery. We investigated four different… CONTINUE READING
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