Pulmonary nocardiosis: Risk factors and outcomes

@article{Toms2007PulmonaryNR,
  title={Pulmonary nocardiosis: Risk factors and outcomes},
  author={Raquel Mart{\'i}nez Tom{\'a}s and Rosario Men{\'e}ndez Villanueva and S. Reyes Calzada and Maruja Santos Durantez and J. M. Tarazona and Manuel Modesto Alapont and Miguel Gobernado Serrano},
  journal={Respirology},
  year={2007},
  volume={12},
  pages={394-400}
}
Background and objectives:  Pulmonary nocardiosis (PN) is an infrequent but severe infection caused by Nocardia spp., which can behave either as opportunistic or primary pathogens. The present study identifies the risk factors for PN, clinical symptoms and radiographic features and the factors that affect its prognosis. Methods:  An observational study of all the patients diagnosed with PN over a 13-year period at the authors’ institution. Results:  Thirty-one adult patients were… Expand
Pulmonary nocardiosis: a clinical analysis of 59 cases.
TLDR
Clinicians should be aware that pulmonary nocardiosis can occur even in immunocompetent patients, especially those with an underlying pulmonary disease, and TMP-SMZ resistance are associated with increased risk of mortality. Expand
Pulmonary Nocardiosis: A Clinical Analysis of 30 Cases
TLDR
The outcome was relatively poor, with a 1-year survival rate of 55.4%, and it was particularly poor in patients treated with immunosuppressant agents, indicating that Pulmonary nocardiosis should always be considered in patients presenting with an opportunistic respiratory infection. Expand
Nocardiosis: Risk Factors, Clinical Characteristics and Outcome
TLDR
In 17 patients (81%), Nocardiosis was limited to respiratory tract and in 4 cases (19%) it was disseminated with multi organ involvement, and two cases (9.5%) died in hospital. Expand
Pulmonary Nocardiosis in Patients With COPD: Characteristics and Prognostic Factors
TLDR
PN affects patients with moderate-severe COPD and has high short- and mid-term mortality rates and factors associated with mortality included previous systemic corticosteroid treatment, less than three months of specific antibiotic therapy and active associated neoplasm. Expand
Clinical correlates of nocardiosis
TLDR
In conclusion, corticosteroid therapy was strongly correlated with nocardiosis, particularly among individuals with chronic pulmonary disease and in pulmonary nocardia, and the positive association between solid organ transplantation and nocardiotic was attenuated following adjustment for systemic cortic Fosteroids in a multivariable model. Expand
ulmonary Nocardiosis in Patients With COPD : Characteristics and Prognostic actors
Introduction: Pulmonary nocardiosis (PN) is a severe infection with a high morbidity and mortality that mainly affects immunocompromised patients. In recent years, an increase in PN cases has beenExpand
Pulmonary Nocardiasis Among Suspected Cases of Pulmonary Tuberculosis in Pune , India ”
Introduction: Pulmonary nocardiosis (PN) is a severe infection, infecting both immunocompromised and immunocompetent patients. It mimicks tuberculosis of lung or can occur along with tuberculosis asExpand
Pulmonary nocardiosis in southern Taiwan.
TLDR
Higher mortality rate in patients with pulmonary nocardiosis was related to disease severity and acute and subacute infection, and N cyriacigeorgica was the most common pathogen in southern Taiwan. Expand
Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis
TLDR
It is important to keep in mind, and suspect the presence of pulmonary nocardiosis in the immunodepressed patients with clinical pulmonary infection, and the laboratory should be notified when Nocardia is suspected in a clinical specimen so that measures can be taken to optimize recognition and recovery of the organism. Expand
Nocardia Bloodstream Infection: A Retrospective Clinical Analysis of Seven Cases in a Single Centre
TLDR
Nocardia bacteremia is a rare bloodstream infection that usually occurs in immunocompromised patients and often causes multiple organ involvement, and early diagnosis and prompt aggressive interventions are important to improve the outcome of this disease. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Pulmonary infection with Nocardia species: a report of 10 cases and review.
TLDR
Pulmonary nocardiosis is difficult to diagnose, diagnosis is frequently delayed and a high level of suspicion is, thus, required in patients with underlying diseases or chronic corticosteroid therapy; there is frequent dissemination and high mortality; and antimicrobial combinations with proven synergy, such as imipenem and amikacin, are recommended for initial therapy. Expand
Pulmonary Nocardiosis: Clinical Experience in Ten Cases
TLDR
Nocardia presents as a subacute or chronic pulmonary infection, mainly outside the hospital, and tends to attack patients with underlying COPD, or immunodepressed patients treated with glucocorticoids, or patients with HIV infection. Expand
Infection with Nocardia Species: Clinical Spectrum of Disease and Species Distribution in Madrid, Spain, 1978–2001
TLDR
Although most patients develop active disease, pulmonary colonization might not be as rare as has generally been assumed and many patients may remain free of nocardial disease for a prolonged period. Expand
Nocardial infections in the immunocompromised host: A detailed study in a defined population.
TLDR
The results of the study suggest that a favorable therapeutic outcome may be anticipated in such individuals who sustain nocardiosis if the diagnosis is made early in the course of the infection and if appropriate antimicrobial therapy is instituted. Expand
Pulmonary nocardiosis re-visited: experience of 35 patients at diagnosis.
TLDR
In this population, the predominant risk factors were immuno-compromised state, corticosteroid therapy, and underlying pulmonary pathology, and the presenting features were similar to those previously described but disseminated infection was not common. Expand
Recent experiences with nocardial infections
TLDR
Analysis of underlying disease and predisposing factors suggests that bronchopulmonary abnormalities predispose to colonization but infection is unusual without immunosuppression. Expand
Nocardiosis in 30 patients with advanced human immunodeficiency virus infection: clinical features and outcome.
TLDR
A total of 30 patients with nocardiosis and infection due to human immunodeficiency virus type 1 (HIV-1) were identified in this institution between January 1985 and June 1989; delayed diagnosis, extensive disease, and early discontinuation of treatment were associated with poor outcome. Expand
The radiographic appearance of pulmonary nocardiosis associated with AIDS.
TLDR
Although the radiographic picture is variable, nocardiosis should be suspected in an HIV-positive patient who has subacute pulmonary disease with an unexplained lung mass or cavitary lesions. Expand
Nocardial infections in the United States, 1972-1974.
TLDR
Nocardial infections occurred in a random geographic distribution within this country, with affected males outnumbering females by 3:1, and most patients were between the ages of 21 and 50 years; however, the age range was broad. Expand
Actinomycosis and nocardiosis. A review of basic differences in therapy.
TLDR
Both actinomycosis and nocardiosis, like tuberculosis, are chronic diseases and a dramatic response to therapy should not be expected; therefore, in both diseases the earlier treatment is instituted the greater the chance for cure. Expand
...
1
2
3
...