Pulmonary neuroepithelial bodies are polymodal airway sensors: evidence for CO2/H+ sensing.

@article{Livermore2015PulmonaryNB,
  title={Pulmonary neuroepithelial bodies are polymodal airway sensors: evidence for CO2/H+ sensing.},
  author={Simon Livermore and Yu-qing Zhou and Jie Pan and Herman Yeger and Colin A Nurse and Ernest Cutz},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={308 8},
  pages={
          L807-15
        }
}
Pulmonary neuroepithelial bodies (NEB) in mammalian lungs are thought to function as airway O2 sensors that release serotonin (5-HT) in response to hypoxia. Direct evidence that NEB cells also respond to airway hypercapnia/acidosis (CO2/H(+)) is presently lacking. We tested the effects of CO2/H(+) alone or in combination with hypoxia on 5-HT release from intact NEB cells in a neonatal hamster lung slice model. For the detection of 5-HT release we used carbon fiber amperometry. Fluorescence Ca(2… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Functional imaging of the pulmonary neuroepithelial body microenvironment

  • I DeProost, InI Pinelto Beouns, +4 authors D. Adriaensen
  • Am J Respir Cell Mol Biol
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…