Pulmonary neuroendocrine cells: Decreased serotonin fluorescence and stable argyrophil-cell numbers in acute hypoxia

@article{Keith1981PulmonaryNC,
  title={Pulmonary neuroendocrine cells: Decreased serotonin fluorescence and stable argyrophil-cell numbers in acute hypoxia},
  author={Dr. Inge M. Keith and Lee A. Wiley and James A. Will},
  journal={Cell and Tissue Research},
  year={1981},
  volume={214},
  pages={201-205}
}
We recorded serotonin-emission intensity using formalin induced fluorescence and counted the number of neuroendocrine cells (NEC's) and neuroepithelial bodies (NEB's) containing argyrophil granules. Comparison of serotonin-emission intensity in NEB's of acutely hypoxic neonates (520 mmHg for 2–21/2 h) and normoxic controls showed significantly lower fluorescence in hypoxic animals. Neuroendocrine cell numbers as shown with Grimelius silver-nitrate stain did not change. This suggests either that… CONTINUE READING