Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury.

  title={Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury.},
  author={Katerina Vaporidi and Eleni Vergadi and Evangelos Kaniaris and Maria Hatziapostolou and Eleni Lagoudaki and Dimitrios Georgopoulos and Warren M. Zapol and Kenneth D. Bloch and Dimitris Iliopoulos},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={303 3},
The aim of this study was to investigate the changes induced by high tidal volume ventilation (HVTV) in pulmonary expression of micro-RNAs (miRNAs) and identify potential target genes and corresponding miRNA-gene networks. Using a real-time RT-PCR-based array in RNA samples from lungs of mice subjected to HVTV for 1 or 4 h and control mice, we identified 65 miRNAs whose expression changed more than twofold upon HVTV. An inflammatory and a TGF-β-signaling miRNA-gene network were identified by in… CONTINUE READING


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