Pulmonary lesion induced by low and high positive end-expiratory pressure levels during protective ventilation in experimental acute lung injury.

@article{Pssaro2009PulmonaryLI,
  title={Pulmonary lesion induced by low and high positive end-expiratory pressure levels during protective ventilation in experimental acute lung injury.},
  author={Caroline Pinto P{\'a}ssaro and Pedro L Silva and Andr{\'e}ia F. Rzezinski and S. A. Abrantes and Viviane R Santiago and Liliane M. Nardelli and Raquel Souza Santos and Carolina Monteiro de Lemos Barbosa and Marcelo Marcos Morales and Walter Ara{\'u}jo Zin and Marcelo Britto Passos Amato and Vera L{\'u}cia Capelozzi and Paolo Pelosi and Patricia R M Rocco},
  journal={Critical care medicine},
  year={2009},
  volume={37 3},
  pages={1011-7}
}
OBJECTIVE To investigate the effects of low and high levels of positive end-expiratory pressure (PEEP), without recruitment maneuvers, during lung protective ventilation in an experimental model of acute lung injury (ALI). DESIGN Prospective, randomized, and controlled experimental study. SETTING University research laboratory. SUBJECTS Wistar rats were randomly assigned to control (C) [saline (0.1 mL), intraperitoneally] and ALI [paraquat (15 mg/kg), intraperitoneally] groups… CONTINUE READING

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