Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume

@article{ZeidlerErdely2008PulmonaryIA,
  title={Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume},
  author={Patti C. Zeidler-Erdely and Michael L. Kashon and Lori A. Battelli and S H Young and Aaron D. Erdely and Jenny R. Roberts and Steven H. Reynolds and James M· Antonini},
  journal={Particle and Fibre Toxicology},
  year={2008},
  volume={5},
  pages={12 - 12}
}
Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 μg of gas metal arc-mild steel (GMA-MS), GMA-stainless steel… CONTINUE READING

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