Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection

@inproceedings{Fujimoto2017PulmonaryIA,
  title={Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection},
  author={Yousuke Fujimoto and Shunji Hasegawa and Takeshi Matsushige and Hiroyuki Wakiguchi and Tamaki Nakamura and Hideki Hasegawa and Noriko Nakajima and Akira Ainai and Atsunori Oga and Hiroshi Itoh and Komei Shirabe and Shoichi Toda and Ryo Atsuta and Tsuneo Morishima and Shouichi Ohga},
  booktitle={Scientific Reports},
  year={2017}
}
Asthmatic patients present more rapid progression of respiratory distress after A(H1N1)pdm09 influenza infection than after seasonal infection. Here, we sought to clarify the pathophysiology of early deterioration in asthmatic patients after A(H1N1)pdm09 infection. Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. In asthma/A(H1N1)pdm09 mice, IL-6 and TNF-α levels peaked at 3 days post… CONTINUE READING