Pulmonary hypoxic vasoconstriction: how strong? How fast?

  title={Pulmonary hypoxic vasoconstriction: how strong? How fast?},
  author={Deborah Sheehan and Robert A. Klocke and Leon E. Farhi},
  journal={Respiration physiology},
  volume={87 3},
We have developed a minimally invasive technique for studying regional blood flow in conscious sheep, bypassing the complications of open-chest surgery, flow probes and tracer infusion. We quantitate regional perfusion continuously on the basis of regional clearance of methane (methane is produced in the sheep rumen, enters the circulation and is eliminated nearly completely (greater than 95%) in the lung). Tracheal intubation with a dual-lumen catheter isolates the gas exchange of the right… CONTINUE READING


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