Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.

@article{Zhao2001PulmonaryHI,
  title={Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.},
  author={Jingsong Zhao and Hui Chen and Jacques J. Peschon and Wei Shi and Yufang Zhang and Stuart J. Frank and David Warburton},
  journal={Developmental biology},
  year={2001},
  volume={232 1},
  pages={204-18}
}
Many membrane-bound protein precursors, including cytokines and growth factors, are proteolytically shed to yield soluble intercellular regulatory ligands. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE/ADAM-17), is a transmembrane metalloprotease-disintegrin that cleaves multiple cell surface proteins, although it was initially identified for the enzymatic release of tumor necrosis factor-alpha (TNF-alpha). Mammalian lung growth and development are tightly… CONTINUE READING

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